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Product Specifications

Item Specification Product Name Saccharomyces boulardii Abbreviation S. boulardii CAS Number 6297-11-6 Strain Classification Non-Pathogenic Probiotic Yeast, Genus Saccharomyces Appearance Light Yellow to Off-White Fine Freeze-Dried Powder Viable Cell Count ≥ 10 Billion CFU/g (Customizable up to 200 Billion CFU/g) Test Method Plate Count / HPLC Shelf Life 24 Months Storage Condition Store in a Cool, Dry Place, Sealed Away from Direct Strong Light and Excess Moisture

Why Is Saccharomyces boulardii So Popular?

The growing global popularity of Saccharomyces boulardii is closely linked to the booming gut health science awareness, alongside decades of verified clinical research confirming its uniquely stable probiotic properties that set it apart from common lactic acid bacteria probiotics. As a non-pathogenic, heat-resistant, yeast-based probiotic first isolated from lychee fruit skin, Saccharomyces boulardii plays irreplaceable essential roles across multiple critical gastrointestinal processes:

• Intestinal flora balance regulation during and after antibiotic treatment
• Pathogenic harmful bacteria displacement and exclusion
• Intestinal barrier function repair and maintenance
• Acute and chronic diarrhea symptom relief
• Gastrointestinal tract immune response modulation

Research shows that regular lactic acid bacteria probiotics are often easily killed by antibiotics and cannot survive passing through the acidic gastric environment. Saccharomyces boulardii is naturally resistant to antibiotics, stomach acid and bile, and will not integrate into the gut's permanent microbiome, delivering completely safe and effective transient probiotic support. This unique property has made Saccharomyces boulardii a cornerstone ingredient of the modern travel wellness, antibiotic companion and gut emergency support supplement category.

Key Benefits of Saccharomyces boulardii

• 1. Naturally Antibiotic Resistant, Works Perfectly Alongside Antibiotic Treatment

Unlike common lactic acid bacteria probiotics that get completely killed by antibiotics, Saccharomyces boulardii as a yeast strain is not affected by antibacterial antibiotics at all. It is the ideal probiotic companion that prevents antibiotic-associated diarrhea and gut flora disruption while users are taking antibiotic medications.

• 2. Effectively Displaces Pathogenic Harmful Bacteria

Saccharomyces boulardii competitively excludes and displaces common harmful gastrointestinal pathogens such as Clostridioides difficile, E. coli and Candida albicans in the gut, blocking them from attaching to the intestinal wall, effectively stopping pathogen infection and rapid colonization, and quickly restoring a balanced healthy digestive environment.

• 3. Withstands Extreme Gastric Acid and Bile Environment

Saccharomyces boulardii has extremely high tolerance to stomach acid and bile salts, it will not be degraded and inactivated during passage through the digestive tract, and can reach the intestinal tract 100% alive to perform its probiotic functions, no special enteric-coated delivery technology is required for common formulation scenarios.

• 4. Rapidly Relieves Diarrhea and Restores Digestive Regularity

Massive clinical studies have proven that daily supplementation of Saccharomyces boulardii can effectively shorten the duration of acute diarrhea, prevent travelers' diarrhea when traveling abroad, and relieve the symptoms of chronic loose stools, delivering fast and reliable digestive recovery support.

• 5. Zero Risk of Permanent Gut Colonization

Saccharomyces boulardii will be completely excreted from the body within 3-5 days after users stop taking it, no risk of long-term permanent colonization or gene transfer to the body's native bacteria, which is completely safe for long-term use by all consumer groups including children, pregnant women and seniors.

Applications

Saccharomyces boulardii is widely used across multiple fast-growing product categories, including:

• Antibiotic Companion Probiotic Supplements
• Travel Wellness and Traveler's Diarrhea Prevention Products
• Acute and Chronic Diarrhea Relief Formulations
• Intestinal Barrier Repair and Digestive Recovery Products
• Children's Gentle Gut Support Probiotic Products
• Post-Gastroenteritis Gut Rebuilding Supplements
• Immune Modulation and Digestive Immunity Wellness Products
• Special Medical Purpose Nutritional Food Formulations

Common dosage forms include:

• Freeze-Dried Powder Blends
• Stick Packs
• Vegetarian Capsules
• Easy-to-Swallow Tablets
• Chewable Probiotic Tablets
• Probiotic Gummy Formulations
• Infant and Children's Nutritional Additives
• Functional Beverage Fortifiers

Saccharomyces boulardii vs Other Common Probiotic Ingredients

While the probiotic and gut wellness category continues to expand, Saccharomyces boulardii remains one of the most clinically validated, unique yeast probiotic ingredients with unmatched stability and performance for antibiotic companion and emergency digestive support.

Ingredient Primary Function Saccharomyces boulardii Antibiotic-Resistant Yeast Probiotic, Pathogen Displacement, Fast Diarrhea Relief Lactobacillus Acidophilus Common Lactic Acid Bacteria Probiotic, Intestinal Flora Balance Support Bifidobacterium Longum Native Gut Bifidobacteria, Long-Term Gut Barrier Nourishment GOS (Galactooligosaccharides) Natural Breast-Milk Derived Prebiotic, Ultra-High Tolerance Inulin Natural Chicory Prebiotic Fiber, Soluble Dietary Fiber Support NMN NAD+ Precursor for Full-Body Cellular Energy and Healthy Aging

Many leading probiotic brands combine Saccharomyces boulardii with complementary ingredients such as prebiotics, zinc or electrolytes to create comprehensive synergistic digestive recovery formulations tailored for different user scenarios such as travel and post-antibiotic gut rebuilding.

Market Opportunity

The global gut health and probiotic market continues to experience strong double-digit growth as consumers increasingly prioritize reliable, clinically validated digestive wellness products. Several key trends are continuously driving rising market demand for Saccharomyces boulardii:

• Global booming public awareness of gut health science and probiotic safety
• Fast expansion of the travel wellness and antibiotic companion supplement market
• Rising consumer preference for highly stable probiotic ingredients that do not require strict cold chain transport
• Growing demand for gentle, effective diarrhea relief products without side effects for children and seniors
• Widely recognized clinical safety and performance profile with decades of global research verification

As a result, Saccharomyces boulardii remains one of the most commercially attractive, high-growth potential ingredients for brands developing next-generation reliable probiotic wellness products.

Frequently Asked Questions

1.What is Saccharomyces boulardii?
Saccharomyces boulardii is a unique non-pathogenic probiotic yeast, first isolated from lychee fruit skin, that is naturally resistant to antibiotics, stomach acid and bile, providing fast and effective digestive balance and pathogen displacement support.

2.Is Saccharomyces boulardii safe for long-term consumption?
Yes. Saccharomyces boulardii has been granted GRAS (Generally Recognized As Safe) status by global major food and drug regulatory authorities, with more than 40 years of clinical application history, zero reported serious adverse events, it is completely safe for all age groups including infants, pregnant women and the elderly.

3.What is the difference between Saccharomyces boulardii and common lactic acid bacteria probiotics?
Saccharomyces boulardii as a yeast is 100% resistant to antibiotics, stomach acid and bile, no enteric coating required, cannot be colonized permanently in the gut, making it the only choice for probiotic supplementation while users are taking antibiotics, a benefit that no regular lactic acid bacteria probiotics can provide.

4.What formulations can Saccharomyces boulardii be used in?
Saccharomyces boulardii features far higher stability than regular lactic acid bacteria, it does not require strict low-temperature cold chain transport, suitable for powder blends, stick packs, capsules, tablets, chewable tablets, gummies and nearly all common probiotic supplement application scenarios.

5.What viable cell count level is typically available?
Premium food-grade Saccharomyces boulardii is commonly supplied with viable cell count ranging from 10 Billion CFU/g up to 200 Billion CFU/g to meet different formulation requirements, fully meeting global probiotic food safety standards.

Looking for a Reliable Saccharomyces boulardii Supplier?

As demand for high-quality clinically validated probiotic products continues to grow, strain purity, viable cell count consistency, no contamination of harmful bacteria and supply reliability have become increasingly critical for supplement brands and manufacturers.

Nutrient Trail supplies high-purity Saccharomyces boulardii designed for dietary supplement, functional food, and special medical nutritional product applications. Comprehensive technical documentation, including specifications, COA, strain identity certificate and full quality assurance information, is available to support your product development and commercialization.